Dermal sensitivity to different doses of spherulin and coccidioidin.

Spherotin, a new reagent, was compared with coccididdin in subjects nonreactive to the standnrd dew of either refor eliciting delayed dermal hypersensitivity in 298 human agent. Severe local reactions were encountered in only subjects living in an area endemic for Coccidioides imooe subM these reactions were produced by the low mi& As standard (dilute) doses, spherulin detected 32 doses of both coccidioidin and spherulin. Evidence is prepercent more reactors than coccidioidii. A tenfdd higher sented that latent sensitivity to coccidioidin can be made concentration of spbedh showed a 50 percent higher apparent by a reaction to spberulin. reactor ratio than did a tenfold higher dose of coccididdin